Regenerative Injection Therapy

Patient Information Guide | Pathways Foot & Ankle

Healing, Not Just Masking Pain

Unlike cortisone injections—which suppress inflammation and can damage local tissues with repeated use—regenerative injection therapies support your body's natural healing process. There is no limit on the number of treatments, and they work with your tissues, not against them.

Key difference: Cortisone blocks inflammation (often a critical part of healing). Regenerative injections stimulate repair — reducing pain by addressing the underlying cause, not just the symptom.

Homeopathic Injectables (Traumeel®, Zeel®, Injeel®)

A combination of diluted plant and mineral extracts (arnica, chamomile, echinacea, calendula, and others). These natural medicines support the body's inflammation-resolution process rather than blocking it entirely. They slow enzymes that break down joint tissue and promote collagen production for healthy cartilage.

  • FDA status: off-label as of 2022, but still used worldwide for musculoskeletal pain and nerve irritation
  • Typical course: 3–5 weekly injections
  • No side effects – Very gentle, plant-based
  • Often used for plantar fasciitis, arthritis, neuromas, and chronic tendinitis

Prolotherapy

A concentrated dextrose and calcium solution is injected into weakened ligaments, tendons, or joints. It creates a mild, controlled irritation that triggers the body's natural healing response — strengthening connective tissue over time.

  • Typical course: 3–6 weekly injections
  • Temporary increase in pain/stiffness for 1–2 days after injection (common – this is the desired healing response)
  • Especially effective for ankle instability, plantar fasciitis, and unresolved sprains
  • Strengthens weak connective tissue over time

Regenerative Protein Array (RPA)

A concentrated blend of growth factors and proteins (PDGF, VEGF, FGF, TGF-β) derived from donor tissue (placental/amniotic). It is acellular (no DNA) and works by stimulating your body's natural healing processes — cell growth, repair, and inflammation reduction.

  • Potent, off-the-shelf option
  • No blood draw required
  • Delivers concentrated repair proteins directly to the injury site
  • Ideal for chronic tendinitis, arthritis, and nerve pain

Quick Comparison

TherapyWhat It IsHow It WorksTypical CourseKey Benefit
Homeopathic (Traumeel/Zeel/Injeel)Plant/mineral extractsSupports natural inflammation resolution3–5 weekly injectionsNo side effects, gentle
ProlotherapyDextrose/calcium solutionCreates mild irritation → triggers healing3–6 weekly injectionsStrengthens weak connective tissue
RPADonor-derived growth factorsDelivers repair proteins directlyVaries by protocolPotent, off-the-shelf

Which Option Is Right for You?

No single injection is best for everyone. The right choice depends on your specific condition, how long you have had symptoms, your treatment goals, and your overall health. Dr. Clifford will help you weigh the options based on the best available evidence.

Conditions We Commonly Treat with Regenerative Injections

  • Plantar Fasciitis
  • Achilles Tendinitis
  • Posterior Tibial Tendinitis
  • Peroneal Tendinitis
  • Morton's Neuroma
  • Tarsal Tunnel Syndrome
  • Peripheral Neuropathy
  • Ankle Instability
  • Arthritis (foot and ankle)

What to Expect at Pathways Foot & Ankle

When you come to see Dr. Clifford for regenerative injection therapy, you can expect:

  • A thorough evaluation, including diagnostic ultrasound when needed
  • A clear explanation of all options, benefits, and risks
  • A personalized treatment plan tailored to your condition
  • In-office injections with minimal discomfort
  • Transparent pricing with no surprise bills
  • Same-day or next-day appointments, no referral needed

Ready to heal from the inside out?

Call Dr. Clifford directly at (971) 359-5299 or visit www.pathwaysfoot.com to schedule your consultation.

216 14th St, Oregon City, OR 97045 | Same-day visits available