Regenerative Injection Therapy
Healing, not just masking pain. Regenerative injections support your body's natural repair process — without steroids, surgery, or the limits of cortisone.
Healing, Not Just Masking Pain
Unlike cortisone injections—which suppress inflammation and can damage local tissues with repeated use—regenerative injection therapies support your body's natural healing process. There is no limit on the number of treatments, and they work with your tissues, not against them.
Homeopathic Injectables (Traumeel®, Zeel®, Injeel®)
A combination of diluted plant and mineral extracts (arnica, chamomile, echinacea, calendula, and others). These natural medicines support the body's inflammation-resolution process rather than blocking it entirely. They slow enzymes that break down joint tissue and promote collagen production for healthy cartilage.
- FDA status: off-label as of 2022, but still used worldwide for musculoskeletal pain and nerve irritation
- Typical course: 3–5 weekly injections
- No side effects – Very gentle, plant-based
- Often used for plantar fasciitis, arthritis, neuromas, and chronic tendinitis
Prolotherapy
A concentrated dextrose and calcium solution is injected into weakened ligaments, tendons, or joints. It creates a mild, controlled irritation that triggers the body's natural healing response — strengthening connective tissue over time.
- Typical course: 3–6 weekly injections
- Temporary increase in pain/stiffness for 1–2 days after injection (common – this is the desired healing response)
- Especially effective for ankle instability, plantar fasciitis, and unresolved sprains
- Strengthens weak connective tissue over time
Regenerative Protein Array (RPA)
A concentrated blend of growth factors and proteins (PDGF, VEGF, FGF, TGF-β) derived from donor tissue (placental/amniotic). It is acellular (no DNA) and works by stimulating your body's natural healing processes — cell growth, repair, and inflammation reduction.
- Potent, off-the-shelf option
- No blood draw required
- Delivers concentrated repair proteins directly to the injury site
- Ideal for chronic tendinitis, arthritis, and nerve pain
Quick Comparison
Homeopathic (Traumeel/Zeel/Injeel)
Prolotherapy
RPA
Which Option Is Right for You?
No single injection is best for everyone. The right choice depends on your specific condition, how long you have had symptoms, your treatment goals, and your overall health. Dr. Clifford will help you weigh the options based on the best available evidence.
Conditions We Commonly Treat with Regenerative Injections
- Plantar Fasciitis
- Achilles Tendinitis
- Posterior Tibial Tendinitis
- Peroneal Tendinitis
- Morton's Neuroma
- Tarsal Tunnel Syndrome
- Peripheral Neuropathy
- Ankle Instability
- Arthritis (foot and ankle)
Frequently Asked Questions
Are regenerative injections safe?
Yes, when performed by a trained physician. Homeopathic injectables and prolotherapy solutions are well tolerated, with a low risk of side effects. RPA is acellular (no DNA) and derived from donor tissue that is screened and processed. Any injection carries a small risk of infection, bleeding, or temporary soreness — we'll discuss your specific situation at your visit.
How many treatments will I need?
Homeopathic injectables typically run 3–5 weekly sessions. Prolotherapy typically runs 3–6 weekly sessions. RPA protocols vary based on the condition. We'll reassess at each visit and adjust based on your response.
How do these compare to cortisone?
Cortisone suppresses inflammation and can provide rapid relief, but it doesn't heal tissue and repeated use can weaken tendons. Regenerative injections are designed to support tissue repair. Many patients use both at different stages — cortisone for a rapid flare, regenerative injections for longer-term healing.
Will I need to take time off work?
Most patients return to work the same day. Prolotherapy can cause temporary soreness or stiffness for 1–2 days, which is expected. We'll advise you on activity restrictions based on the specific therapy and location.
What to Expect at Pathways Foot & Ankle
- A thorough evaluation, including diagnostic ultrasound when needed
- A clear explanation of all options, benefits, and risks
- A personalized treatment plan tailored to your condition
- In-office injections with minimal discomfort
- Transparent pricing with no surprise bills
- Same-day or next-day appointments, no referral needed
Take the next step — reach out today
Pathways Foot & Ankle - Dr. Craig Clifford
216 14th St, Oregon City, OR 97045
(971) 359-5299 — Call Dr. Clifford directly
Same-day & next-day appointments available, no referral needed
House calls also available throughout the region.